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MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease

Polyglutamine (polyQ) tract expansion leads to proteotoxic misfolding and drives a family of nine diseases. We study spinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder of the neuromuscular system caused by the polyQ androgen receptor (AR). Using a knock-in mouse model of...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol
Main Authors: Nath, Samir R., Lieberman, Matthew L., Yu, Zhigang, Marchioretti, Caterina, Jones, Samuel T., Danby, Emily C. E., Van Pelt, Kate M., Sorarù, Gianni, Robins, Diane M., Bates, Gillian P., Pennuto, Maria, Lieberman, Andrew P.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166004/
https://ncbi.nlm.nih.gov/pubmed/32306066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02156-4
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