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The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD‐L1 levels on CNS cells

Central nervous system (CNS) cells locally modulate immune responses using numerous molecules that are not fully elucidated. Engagement of programmed death‐1 (PD‐1), expressed on activated T cells, by its ligands (PD‐L1 or PD‐L2) suppresses T‐cell responses. Enhanced CNS PD‐1 and PD‐L1 expression ha...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Pittet, Camille L., Newcombe, Jia, Antel, Jack P., Arbour, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165507/
https://ncbi.nlm.nih.gov/pubmed/21360758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21158
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