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Relative bioavailability of a pediatric dispersible tablet and adult film‐coated tablet of macitentan in healthy volunteers

To compare the pharmacokinetic (PK) properties of the pediatric dispersible tablet formulation of macitentan and the adult film‐coated tablet formulation of macitentan in healthy subjects. A randomized, open‐label, single‐dose, two‐sequence, two‐period, crossover, Phase 1 study was conducted in 12 h...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pharmacol Res Perspect
Auteurs principaux: Sidharta, Patricia N., Štěpánová, Radka, Globig, Susanne, Ulč, Ivan, Csonka, Dénes
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164404/
https://ncbi.nlm.nih.gov/pubmed/32302056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.580
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