Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients

AIMS: Fanconi anaemia (FA) is a rare disorder characterized by progressive bone marrow failure that requires haematopoietic cell transplantation (HCT). Busulfan is used in conditioning regimens prior to HCT. Doses used in non‐FA patients cause life‐threatening toxicities in FA patients and data on b...

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Publicat a:Br J Clin Pharmacol
Autors principals: van Hoogdalem, Matthijs W., Emoto, Chie, Fukuda, Tsuyoshi, Mizuno, Tomoyuki, Mehta, Parinda A., Vinks, Alexander A.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163375/
https://ncbi.nlm.nih.gov/pubmed/31851762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14202
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