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Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin

AIMS: Two phase 1, open‐label studies were conducted to investigate the effect of renal impairment (RI) and organic anion transporter (OAT) inhibition on pharmacokinetics (PK) and safety of relebactam (REL) plus imipenem/cilastatin (IMI). METHODS: Study PN005 evaluated the PK of REL (125 mg) plus IM...

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書誌詳細
出版年:Br J Clin Pharmacol
主要な著者: Bhagunde, Pratik, Colon‐Gonzalez, Francheska, Liu, Yang, Wu, Jin, Xu, Shiyao Sherrie, Garrett, Graigory, Jumes, Patricia, Lasseter, Kenneth, Marbury, Thomas, Rizk, Matthew L., Lala, Mallika, Rhee, Elizabeth G., Butterton, Joan R., Boundy, Keith
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163372/
https://ncbi.nlm.nih.gov/pubmed/31856304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14204
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