Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CARD domain (ASC) which polymerizes into filaments re...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Chevriaux, Angélique, Pilot, Thomas, Derangère, Valentin, Simonin, Harmonie, Martine, Pierre, Chalmin, Fanny, Ghiringhelli, François, Rébé, Cédric
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162607/
https://ncbi.nlm.nih.gov/pubmed/32328491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00167
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