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Inhibition of host protein synthesis by Sindbis virus: correlation with viral RNA replication and release of nuclear proteins to the cytoplasm

Infection of mammalian cells by Sindbis virus (SINV) profoundly blocks cellular mRNA translation. Experimental evidence points to viral non‐structural proteins (nsPs), in particular nsP2, as the mediator of this inhibition. However, individual expression of nsP1, nsP2, nsP3 or nsP1‐4 does not block...

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Detalhes bibliográficos
Publicado no:Cell Microbiol
Main Authors: Sanz, Miguel A., García‐Moreno, Manuel, Carrasco, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162411/
https://ncbi.nlm.nih.gov/pubmed/25329362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12381
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