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Inhibition of host protein synthesis by Sindbis virus: correlation with viral RNA replication and release of nuclear proteins to the cytoplasm

Infection of mammalian cells by Sindbis virus (SINV) profoundly blocks cellular mRNA translation. Experimental evidence points to viral non‐structural proteins (nsPs), in particular nsP2, as the mediator of this inhibition. However, individual expression of nsP1, nsP2, nsP3 or nsP1‐4 does not block...

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Bibliografische gegevens
Gepubliceerd in:Cell Microbiol
Hoofdauteurs: Sanz, Miguel A., García‐Moreno, Manuel, Carrasco, Luis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162411/
https://ncbi.nlm.nih.gov/pubmed/25329362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12381
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