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Inhibition of host protein synthesis by Sindbis virus: correlation with viral RNA replication and release of nuclear proteins to the cytoplasm

Infection of mammalian cells by Sindbis virus (SINV) profoundly blocks cellular mRNA translation. Experimental evidence points to viral non‐structural proteins (nsPs), in particular nsP2, as the mediator of this inhibition. However, individual expression of nsP1, nsP2, nsP3 or nsP1‐4 does not block...

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Vydáno v:Cell Microbiol
Hlavní autoři: Sanz, Miguel A., García‐Moreno, Manuel, Carrasco, Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162411/
https://ncbi.nlm.nih.gov/pubmed/25329362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12381
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