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Synthesis and Antiviral Properties of Spirocyclic [1,2,3]‐Triazolooxazine Nucleosides

An efficient synthesis of spirocyclic triazolooxazine nucleosides is described. This was achieved by the conversion of β‐d‐psicofuranose to the corresponding azido‐derivative, followed by alkylation of the primary alcohol with a range of propargyl bromides, obtained by Sonogashira chemistry. The pro...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Dell'Isola, Antonio, McLachlan, Matthew M. W., Neuman, Benjamin W., Al‐Mullah, Hawaa M. N., Binks, Alexander W. D., Elvidge, Warren, Shankland, Kenneth, Cobb, Alexander J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY‐VCH Verlag 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162048/
https://ncbi.nlm.nih.gov/pubmed/25082061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201403560
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