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Structure of aminopeptidase N from Escherichia coli complexed with the transition‐state analogue aminophosphinic inhibitor PL250

Aminopeptidase N (APN; EC 3.4.11.2) purified from Escherichia coli has been crystallized with the optically pure aminophosphinic inhibitor PL250, H(3)N(+)‐CH(CH(3))‐P(O)(OH)‐CH(2)‐CH(CH(2)Ph)‐CONH‐CH(CH(2)Ph)CO(2) (−), which mimics the transition state of the hydrolysis reaction. PL250 inhibits APN...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr D Biol Crystallogr
Main Authors: Fournié‐Zaluski, Marie‐Claude, Poras, Hervé, Roques, Bernard P., Nakajima, Yoshitaka, Ito, Kiyoshi, Yoshimoto, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161626/
https://ncbi.nlm.nih.gov/pubmed/19622865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744490901779X
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