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Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor
A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in the nanomolar range. These derivatives behave as the most potent APN inhibitors designe...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Published by Elsevier Ltd.
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7172755/ https://ncbi.nlm.nih.gov/pubmed/10386926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0960-894X(99)00219-X |
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