Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the formation of large tissue destructive lesions in the...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Tsymala, Irina, Nigritinou, Magdalini, Zeka, Bleranda, Schulz, Rouven, Niederschick, Felix, Matković, Mia, Bauer, Isabel J., Szalay, Michael, Schanda, Kathrin, Lerch, Magdalena, Misu, Tatsuro, Fujihara, Kazuo, Bennett, Jeffrey L., Dahle, Charlotte, Pache, Florence, Rommer, Paulus, Leutmezer, Fritz, Illes, Zsolt, Leite, Maria Isabel, Palace, Jacqueline, Scholze, Petra, Reindl, Markus, Lassmann, Hans, Bradl, Monika
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160927/
https://ncbi.nlm.nih.gov/pubmed/32293546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00920-x
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