Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation

BACKGROUND & AIMS: Claudin-7 (Cldn7) is a tight junction (TJ) membrane protein located at the apical TJ and basolateral side of intestinal epithelial cells. Deletion of Cldn7 by gene targeting leads to the inflammatory bowel disease–like phenotype in mice, which includes weight loss, diarrhea, m...

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Bibliografiske detaljer
Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Xing, Tiaosi, Benderman, Lesley Jasmine, Sabu, Stephiya, Parker, Joel, Yang, Jeffrey, Lu, Qun, Ding, Lei, Chen, Yan-Hua
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160575/
https://ncbi.nlm.nih.gov/pubmed/31874254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.12.005
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