Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription

Overactivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare...

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Udgivet i:Oncogene
Main Authors: Lucia, Kristin, Wu, Yonghe, Garcia, Jose Monteserin, Barlier, Anne, Buchfelder, Michael, Saeger, Wolfgang, Renner, Ulrich, Stalla, Günter K., Theodoropoulou, Marily
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160059/
https://ncbi.nlm.nih.gov/pubmed/32111982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1223-6
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