Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription

Overactivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare...

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Publicado en:Oncogene
Autores principales: Lucia, Kristin, Wu, Yonghe, Garcia, Jose Monteserin, Barlier, Anne, Buchfelder, Michael, Saeger, Wolfgang, Renner, Ulrich, Stalla, Günter K., Theodoropoulou, Marily
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160059/
https://ncbi.nlm.nih.gov/pubmed/32111982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1223-6
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