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Dantrolene ameliorates impaired neurogenesis and synaptogenesis in Induced Pluripotent Stem Cell lines derived from patients with Alzheimer’s disease

BACKGROUND: Overactivation of ryanodine receptors and the resulting impaired calcium homeostasis contribute to Alzheimer’s disease-related pathophysiology. We hypothesized that exposing neuronal progenitors derived from induced pluripotent stems cells of patients with Alzheimer’s disease to dantrole...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Wang, Yong, Liang, Ge, Liang, Shuqing, Mund, Rachel, Shi, Yun, Wei, Huafeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160009/
https://ncbi.nlm.nih.gov/pubmed/32149777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003224
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