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Dantrolene ameliorates impaired neurogenesis and synaptogenesis in Induced Pluripotent Stem Cell lines derived from patients with Alzheimer’s disease
BACKGROUND: Overactivation of ryanodine receptors and the resulting impaired calcium homeostasis contribute to Alzheimer’s disease-related pathophysiology. We hypothesized that exposing neuronal progenitors derived from induced pluripotent stems cells of patients with Alzheimer’s disease to dantrole...
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| Pubblicato in: | Anesthesiology |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7160009/ https://ncbi.nlm.nih.gov/pubmed/32149777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003224 |
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