Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing

Mitochondria play an important role in sensing both acute and chronic hypoxia in the pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to stabilization of the hypoxia-inducible factor (HIF) remains elusive. Alteration of the mitochondrial electron flux and increased...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Sommer, Natascha, Alebrahimdehkordi, Nasim, Pak, Oleg, Knoepp, Fenja, Strielkov, Ievgen, Scheibe, Susan, Dufour, Eric, Andjelković, Ana, Sydykov, Akylbek, Saraji, Alireza, Petrovic, Aleksandar, Quanz, Karin, Hecker, Matthias, Kumar, Manish, Wahl, Joel, Kraut, Simone, Seeger, Werner, Schermuly, Ralph T., Ghofrani, Hossein A., Ramser, Kerstin, Braun, Thomas, Jacobs, Howard T., Weissmann, Norbert, Szibor, Marten
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159913/
https://ncbi.nlm.nih.gov/pubmed/32426457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba0694
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