Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

RATIONALE: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation. Hypoxia-induced mitochondrial superoxide release has been suggested as critical step in the signaling pathway underlying HPV...

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Publicat a:Circ Res
Autors principals: Sommer, Natascha, Hüttemann, Maik, Pak, Oleg, Scheibe, Susan, Knoepp, Fenja, Sinkler, Christopher, Malczyk, Monika, Gierhardt, Mareike, Esfandiary, Azadeh, Kraut, Simone, Jonas, Felix, Veith, Christine, Aras, Siddhesh, Sydykov, Akylbek, Alebrahimdehkordi, Nasim, Giehl, Klaudia, Hecker, Matthias, Brandes, Ralf P., Seeger, Werner, Grimminger, Friedrich, Ghofrani, Hossein A., Schermuly, Ralph T., Grossman, Lawrence I., Weissmann, Norbert
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544581/
https://ncbi.nlm.nih.gov/pubmed/28620066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.310482
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