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Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension

Dysfunction of the NO/sGC/cGMP signaling pathway has been implicated in the pathogenesis of pulmonary hypertension (PH). Therefore, agents stimulating cGMP synthesis via sGC are important therapeutic options for treatment of PH patients. An unwanted effect of this novel class of drugs is their syste...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Amirjanians, Matthieu, Egemnazarov, Bakytbek, Sydykov, Akylbek, Kojonazarov, Baktybek, Brandes, Ralf, Luitel, Himal, Pradhan, Kabita, Stasch, Johannes-Peter, Redlich, Gorden, Weissmann, Norbert, Grimminger, Friedrich, Seeger, Werner, Ghofrani, Hossein, Schermuly, Ralph
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444690/
https://ncbi.nlm.nih.gov/pubmed/28410199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16769
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