Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CL(pro) Inhibitors

SARS CoV 3CL(pro) is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome (SARS). A quinolinone compound 1 was selected via virtual screening, and it was synthetized and tested for enzymatic inhibition in vitro. Compound 1 showed potent i...

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Опубликовано в: :Chin J Chem
Главные авторы: Sun, Yuanpei, Zhang, Ning, Wang, Jian, Guo, Yu, Sun, Bo, Liu, Wei, Zhou, Honggang, Yang, Cheng
Формат: Artigo
Язык:Inglês
Опубликовано: WILEY‐VCH Verlag 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159103/
https://ncbi.nlm.nih.gov/pubmed/32313409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cjoc.201300392
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