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IL1R1 is required for celastrol’s leptin sensitization and anti-obesity effects
Celastrol, a pentacyclic triterpene is the most potent anti-obesity agent that has been reported to date(1). The mechanism of celastrol’s leptin sensitizing and anti-obesity effects has not yet been elucidated. In this study, we identified interleukin 1 receptor 1 (IL1R1) as a mediator of celastrol...
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| הוצא לאור ב: | Nat Med |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7158951/ https://ncbi.nlm.nih.gov/pubmed/30833749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0358-x |
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