IL1R1 is required for celastrol’s leptin sensitization and anti-obesity effects

Celastrol, a pentacyclic triterpene is the most potent anti-obesity agent that has been reported to date(1). The mechanism of celastrol’s leptin sensitizing and anti-obesity effects has not yet been elucidated. In this study, we identified interleukin 1 receptor 1 (IL1R1) as a mediator of celastrol...

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Foilsithe in:Nat Med
Main Authors: Feng, Xudong, Guan, Dongxian, Auen, Thomas, Choi, Jae Won, Salazar Hernández, Mario Andrés, Lee, Jaemin, Chun, Hyonho, Faruk, Farhana, Kaplun, Esther, Herbert, Zachary, Copps, Kyle D., Ozcan, Umut
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158951/
https://ncbi.nlm.nih.gov/pubmed/30833749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0358-x
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