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PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
OBJECTIVE: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression in the liver is highly elevated in obese and diabetic conditions, leading to increased hepatic glucose production. We previously s...
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| Publicado no: | Mol Metab |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784318/ https://ncbi.nlm.nih.gov/pubmed/29129613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.10.010 |
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