CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms

CpG dinucleotides are suppressed in the genomes of many vertebrate RNA viruses, including HIV-1. The cellular antiviral protein ZAP (zinc finger antiviral protein) binds CpGs and inhibits HIV-1 replication when CpGs are introduced into the viral genome. However, it is not known if ZAP-mediated restr...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ficarelli, Mattia, Antzin-Anduetza, Irati, Hugh-White, Rupert, Firth, Andrew E., Sertkaya, Helin, Wilson, Harry, Neil, Stuart J. D., Schulz, Reiner, Swanson, Chad M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158733/
https://ncbi.nlm.nih.gov/pubmed/31748389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01337-19
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