Connexin43 peptide, TAT-Cx43(266–283), selectively targets glioma cells, impairs malignant growth, and enhances survival in mouse models in vivo

BACKGROUND: Malignant gliomas are the most frequent primary brain tumors and remain among the most incurable cancers. Although the role of the gap junction protein, connexin43 (Cx43), has been deeply investigated in malignant gliomas, no compounds have been reported with the ability to recapitulate...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Jaraíz-Rodríguez, Myriam, Talaverón, Rocío, García-Vicente, Laura, Pelaz, Sara G, Domínguez-Prieto, Marta, Álvarez-Vázquez, Andrea, Flores-Hernández, Raquel, Sin, Wun Chey, Bechberger, John, Medina, José M, Naus, Christian C, Tabernero, Arantxa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158688/
https://ncbi.nlm.nih.gov/pubmed/31883012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz243
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