Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs

To address the most appropriate endogenous biomarker for drug–drug interaction risk assessment, eight healthy subjects received an organic anion transporting polypeptide 1B (OATP1B) inhibitor (rifampicin, 150, 300, and 600 mg), and a probe drug cocktail (atorvastatin, pitavastatin, rosuvastatin, and...

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Bibliographic Details
Published in:Clin Pharmacol Ther
Main Authors: Mori, Daiki, Kimoto, Emi, Rago, Brian, Kondo, Yusuke, King‐Ahmad, Amanda, Ramanathan, Ragu, Wood, Linda S., Johnson, Jillian G., Le, Vu H., Vourvahis, Manoli, David Rodrigues, A., Muto, Chieko, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158214/
https://ncbi.nlm.nih.gov/pubmed/31628668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1695
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