PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

The aim of the present study was to establish a physiologically based pharmacokinetic (PBPK) model for coproporphyrin I (CP‐I), a biomarker supporting the prediction of drug‐drug interactions (DDIs) involving hepatic organic anion transporting polypeptide 1B (OATP1B), using clinical DDI data with an...

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Dettagli Bibliografici
Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Yoshikado, Takashi, Toshimoto, Kota, Maeda, Kazuya, Kusuhara, Hiroyuki, Kimoto, Emi, Rodrigues, A. David, Chiba, Koji, Sugiyama, Yuichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263667/
https://ncbi.nlm.nih.gov/pubmed/30175555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12348
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