Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

Hepatitis C virus (HCV) infects millions of people worldwide, causing chronic liver disease that can lead to cirrhosis, hepatocellular carcinoma, and liver transplant. In the last several years, the advent of direct-acting antivirals, including NS3/4A protease inhibitors (PIs), has remarkably improv...

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Enregistré dans:
Détails bibliographiques
Publié dans:mBio
Auteurs principaux: Matthew, Ashley N., Zephyr, Jacqueto, Nageswara Rao, Desaboini, Henes, Mina, Kamran, Wasih, Kosovrasti, Klajdi, Hedger, Adam K., Lockbaum, Gordon J., Timm, Jennifer, Ali, Akbar, Kurt Yilmaz, Nese, Schiffer, Celia A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157764/
https://ncbi.nlm.nih.gov/pubmed/32234812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00172-20
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