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Overexpression of Bcl-2 in the intestinal epithelium prevents sepsis-induced gut barrier function via altering tight junction protein expression

Sepsis induces both intestinal hyperpermeability and epithelial apoptosis. While each has been implicated in mediating sepsis mortality, the relationship between these two processes is unclear. We hypothesized that preventing intestinal apoptosis would prevent gut barrier dysfunction. To test this h...

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Detalhes bibliográficos
Publicado no:Shock
Main Authors: Otani, Shunsuke, Oami, Takehiko, Yoseph, Benyam P., Klingensmith, Nathan J., Chen, Ching-wen, Liang, Zhe, Coopersmith, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156322/
https://ncbi.nlm.nih.gov/pubmed/31626040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001463
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