Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis

Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) phosphorylates the myosin regulatory light chain, resulting in increased permeability. The p...

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Detalles Bibliográficos
Publicado en:Mol Med
Main Authors: Lorentz, C Adam, Liang, Zhe, Meng, Mei, Chen, Ching-Wen, Yoseph, Benyam P, Breed, Elise R, Mittal, Rohit, Klingensmith, Nathan J, Farris, Alton B, Burd, Eileen M, Koval, Michael, Ford, Mandy L, Coopersmith, Craig M
Formato: Artigo
Idioma:Inglês
Publicado: Feinstein Institute for Medical Research 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568914/
https://ncbi.nlm.nih.gov/pubmed/28598488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00256
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