Intestine-Specific Deletion of Microsomal Triglyceride Transfer Protein Increases Mortality in Aged Mice

BACKGROUND: Mice with conditional, intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO) exhibit a complete block in chylomicron assembly together with lipid malabsorption. Young (8–10 week) Mttp-IKO mice have improved survival when subjected to a murine model of Pseudom...

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Hauptverfasser: Liang, Zhe, Xie, Yan, Dominguez, Jessica A., Breed, Elise R., Yoseph, Benyam P., Burd, Eileen M., Farris, Alton B., Davidson, Nicholas O., Coopersmith, Craig M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092051/
https://ncbi.nlm.nih.gov/pubmed/25010671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101828
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