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TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways

CD40 plays an important role in immune responses by activating the c-Jun N-terminal protein kinase (JNK) and NF-κB pathways; however, the precise mechanisms governing the spatiotemporal activation of these two signaling pathways are not fully understood. Here, using four different TRAF2-deficient ce...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Workman, Lauren M., Zhang, Laiqun, Fan, Yumei, Zhang, Weizhou, Habelhah, Hasem
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156217/
https://ncbi.nlm.nih.gov/pubmed/32041822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00429-19
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