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TRAF2 Suppresses Basal IKK Activity in Resting Cells and TNFα can Activate IKK in TRAF2 and TRAF5 Double Knockout Cells
TRAF2 and TRAF5 are adapter proteins involved in TNFα-induced activation of the JNK and NF-κB pathways. Currently, TNFα-induced NF-κB activation is believed to be impaired in TRAF2 and TRAF5 double knockout (T2/5 DKO) cells. Here, we report instead that T2/5 DKO cells exhibit high basal IKK activity...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730456/ https://ncbi.nlm.nih.gov/pubmed/19409903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.054 |
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