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TRAF2 Suppresses Basal IKK Activity in Resting Cells and TNFα can Activate IKK in TRAF2 and TRAF5 Double Knockout Cells

TRAF2 and TRAF5 are adapter proteins involved in TNFα-induced activation of the JNK and NF-κB pathways. Currently, TNFα-induced NF-κB activation is believed to be impaired in TRAF2 and TRAF5 double knockout (T2/5 DKO) cells. Here, we report instead that T2/5 DKO cells exhibit high basal IKK activity...

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Main Authors: Zhang, Laiqun, Blackwell, Ken, Thomas, Gregory S., Sun, Shujie, Yeh, Wen-Chen, Habelhah, Hasem
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730456/
https://ncbi.nlm.nih.gov/pubmed/19409903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.054
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