Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy

BRAF V600 mutation influences cellular signaling pathways for melanoma development. However, the role of oncogenic BRAF in adaptive stress response pathways is not fully understood. Here, we show that oncogenic BRAF plays an essential role in the induction of ATF4 following the activation of general...

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Bibliographic Details
Published in:iScience
Main Authors: Nagasawa, Ikuko, Koido, Masaru, Tani, Yuri, Tsukahara, Satomi, Kunimasa, Kazuhiro, Tomida, Akihiro
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155235/
https://ncbi.nlm.nih.gov/pubmed/32283529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101028
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