The kinase PERK represses translation of the G-protein–coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells

As a branch of the unfolded protein response, protein kinase R-like endoplasmic reticulum kinase (PERK) represses global translation in response to endoplasmic reticulum (ER) stress. This pathophysiological condition is associated with the tumor microenvironment in cancer. Previous findings in our l...

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Vydáno v:J Biol Chem
Hlavní autoři: Okamoto, Yuka, Saito, Takuya, Tani, Yuri, Toki, Tamami, Hasebe, Akiko, Koido, Masaru, Tomida, Akihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135982/
https://ncbi.nlm.nih.gov/pubmed/32107308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010655
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