Extended experience with a non‐cytotoxic DNMT1‐targeting regimen of decitabine to treat myeloid malignancies

The nucleoside analogue decitabine can deplete the epigenetic regulator DNA methyltransferase 1 (DNMT1), an effect that occurs, and is saturated at, low concentrations/doses. A reason to pursue this molecular‐targeted effect instead of the DNA damage/cytotoxicity produced with high concentrations/do...

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Veröffentlicht in:Br J Haematol
Hauptverfasser: Awada, Hassan, Mahfouz, Reda Z., Kishtagari, Ashwin, Kuzmanovic, Teodora, Durrani, Jibran, Kerr, Cassandra M., Patel, Bhumika J., Visconte, Valeria, Radivoyevitch, Tomas, Lichtin, Alan, Carraway, Hetty E., Maciejewski, Jaroslaw P., Saunthararajah, Yogen
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Haematological Malignancy – Clinical
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154732/
https://ncbi.nlm.nih.gov/pubmed/31736067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.16281
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