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Ambident Nucleophilic Substitution: Understanding Non‐HSAB Behavior through Activation Strain and Conceptual DFT Analyses

The ability to understand and predict ambident reactivity is key to the rational design of organic syntheses. An approach to understand trends in ambident reactivity is the hard and soft acids and bases (HSAB) principle. The recent controversy over the general validity of this principle prompted us...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Bettens, Tom, Alonso, Mercedes, De Proft, Frank, Hamlin, Trevor A., Bickelhaupt, F. Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154642/
https://ncbi.nlm.nih.gov/pubmed/31957943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202000272
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