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Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease
Many studies implicate altered cyclic nucleotide signaling in the pathophysiology of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). As such, we explored how phosphodiesterases 2A (PDE2A) and 10A (PDE10A)—enzymes that break down cyclic nucleotides—may be altered in...
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| Publicado no: | Cell Signal |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7153982/ https://ncbi.nlm.nih.gov/pubmed/32119913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2020.109592 |
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