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Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease
Many studies implicate altered cyclic nucleotide signaling in the pathophysiology of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). As such, we explored how phosphodiesterases 2A (PDE2A) and 10A (PDE10A)—enzymes that break down cyclic nucleotides—may be altered in...
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| 出版年: | Cell Signal |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7153982/ https://ncbi.nlm.nih.gov/pubmed/32119913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2020.109592 |
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