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Identification of new phosphodiesterase 9A (PDE9A) isoforms and how their expression and subcellular compartmentalization in brain changes across the lifespan
3′,5′-cyclic nucleotide phosphodiesterases (PDEs) degrade cAMP and cGMP, with PDE9A having the highest affinity for cGMP. We show PDE9A6 and three novel PDE9 isoforms (PDE9X-100, PDE9X-120, PDE9X-175) are reliably detected in brain and lung of mouse, while PDE9A2 and other isoforms are found elsewhe...
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| Publicado no: | Neurobiol Aging |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5871571/ https://ncbi.nlm.nih.gov/pubmed/29505961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.01.019 |
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