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A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribute. To facilitate discovery of glycosyltransferase...

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Bibliographische Detailangaben
Veröffentlicht in:Curr Res Biotechnol
Hauptverfasser: Liang, Chenguang, Chiang, Austin W.T., Hansen, Anders H., Arnsdorf, Johnny, Schoffelen, Sanne, Sorrentino, James T., Kellman, Benjamin P., Bao, Bokan, Voldborg, Bjørn G., Lewis, Nathan E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153765/
https://ncbi.nlm.nih.gov/pubmed/32285041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crbiot.2020.01.001
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