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Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Biosimilar drugs must closely resemble the pharmacological attributes of innovator products to ensure safety and efficacy to obtain regulatory approval. Glycosylation is one critical quality attribute that must be matched, but it is inherently difficult to control due to the complexity of its biogen...

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Bibliographic Details
Published in:Biotechnol J
Main Authors: Spahn, Philipp N., Hansen, Anders H., Kol, Stefan, Voldborg, Bjørn G., Lewis, Nathan E.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293603/
https://ncbi.nlm.nih.gov/pubmed/27860290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201600489
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