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Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region

Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additionally regulated by direct binding of cAMP to a cyclic nucleotid...

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Vydáno v:J Membr Biol
Hlavní autoři: Page, Dana A., Magee, Kaylee E. A., Li, Jessica, Jung, Matthew, Young, Edgar C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150657/
https://ncbi.nlm.nih.gov/pubmed/32146488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-020-00111-8
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