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Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additionally regulated by direct binding of cAMP to a cyclic nucleotid...
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| Veröffentlicht in: | J Membr Biol |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7150657/ https://ncbi.nlm.nih.gov/pubmed/32146488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-020-00111-8 |
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