Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function

Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson’s disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential pathogenesis associate...

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Vydáno v:Neurobiol Dis
Hlavní autoři: Anand, Nikhita, Holcom, Angelina, Broussalian, Michael, Schmidt, Minna, Chinta, Shankar J., Lithgow, Gordon J., Andersen, Julie K., Chamoli, Manish
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150649/
https://ncbi.nlm.nih.gov/pubmed/32032734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104786
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