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Design, synthesis, and biochemical characterization of non-native antagonists of the Pseudomonas aeruginosa quorum sensing receptor LasR with nanomolar IC(50) values

Quorum sensing (QS), a bacterial cell-to-cell communication system mediated by small molecules and peptides, has received significant interest as a potential target to block infection. The common pathogen Pseudomonas aeruginosa uses QS to regulate many of its virulence phenotypes at high cell densit...

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Bibliografske podrobnosti
izdano v:ACS Infect Dis
Main Authors: Manson, Daniel E., O’Reilly, Matthew C., Nyffeler, Kayleigh E., Blackwell, Helen E.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150648/
https://ncbi.nlm.nih.gov/pubmed/32037806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00518
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