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Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa
[Image: see text] Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display p...
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| Published in: | ACS Med Chem Lett |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical
Society
2014
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4329587/ https://ncbi.nlm.nih.gov/pubmed/25699144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500459f |
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