Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa

[Image: see text] Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display p...

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Udgivet i:ACS Med Chem Lett
Main Authors: O’Brien, Kevin T., Noto, Joseph G., Nichols-O’Neill, Luke, Perez, Lark J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329587/
https://ncbi.nlm.nih.gov/pubmed/25699144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500459f
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