The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy

YAP1 is a key mediator of the Hippo pathway capable of exerting a profound effect on organ size as well as tumorigenesis. Alternative mRNA splicing of human YAP1 results in at least 8 protein isoforms that differ within the 2(nd) WW motif and the transcriptional activation domain. Methods: To invest...

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Gepubliceerd in:Theranostics
Hoofdauteurs: Guo, Qiang, Quan, Meiyu, Dong, Jinglai, Bai, Jing, Wang, Jie, Han, Rui, Wang, Wei, Cai, Yaxin, Lv, Yu-Qing, Chen, Qianjie, Xu, Huijing, Lyu, Han-Deng, Deng, Liancheng, Zhou, Depu, Xiao, Xueyuan, De Langhe, Stijn, Billadeau, Daniel D., Lou, Zhenkun, Zhang, Jin-San
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ivyspring International Publisher 2020
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150473/
https://ncbi.nlm.nih.gov/pubmed/32292505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.42795
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